Mazdutide

What people use it for

• Chronic weight management
• Type 2 diabetes

What Mazdutide does in the body

Combines GLP-1 activity (appetite, insulin) with glucagon-receptor activity, which is thought to raise energy expenditure and help burn liver fat. It is related to the oxyntomodulin hormone, which naturally hits both receptors.

Strength of evidence

Moderate: phase 3 trials in China (GLORY, DREAMS programs).

Look up the evidence

• Reviews on PubMed: Summaries of the published research
• Clinical trials on PubMed: Published studies in people
• ClinicalTrials.gov: Registered trials, past and ongoing
• Prescribing information (DailyMed, US): Official US label
• Patient leaflets (emc, UK): Official UK product information

Live searches of official databases. New to the terms? See the glossary.

Reported side effects & risks

• Nausea, diarrhea, vomiting, reduced appetite
• Increased heart rate
• Limited data outside Chinese populations

Who should avoid it or take extra care

• Pregnant or breastfeeding
• Personal or family history of medullary thyroid cancer or MEN2 (expected class caution)
• Past pancreatitis (talk to your doctor first)

Not a complete list. Check with a doctor or pharmacist about your own health and medicines.

Regulatory status

Approved in China for weight management and type 2 diabetes. Not approved in the US or EU.

How it's taken

Route: Injection under the skin once a week

How long it lasts (half-life): Long-acting, designed for weekly dosing