FOXO4-DRI

What people use it for

• Clearing senescent ('zombie') cells for longevity (popular interest)
• Age-related decline (mouse research)

What FOXO4-DRI does in the body

Senescent cells stop dividing but don't die, and release inflammatory signals. FOXO4-DRI disrupts a protein interaction (FOXO4 and p53) that keeps them alive, pushing them to self-destruct. It is made of mirror-image amino acids so it resists breakdown.

Strength of evidence

Very weak: one influential mouse study plus lab work; no human trials.

Look up the evidence

• Reviews on PubMed: Summaries of the published research
• Clinical trials on PubMed: Published studies in people
• ClinicalTrials.gov: Registered trials, past and ongoing

Live searches of official databases. New to the terms? See the glossary.

Reported side effects & risks

• Unknown in humans
• Theoretical risk of harming healthy cells, as it acts on the p53 pathway

Who should avoid it or take extra care

• Pregnant or breastfeeding
• Under 18
• Anyone having cancer treatment (it acts on the p53 pathway)

Not a complete list. Check with a doctor or pharmacist about your own health and medicines.

Regulatory status

Not approved.

How it's taken

Route: Injection (popular use)

How long it lasts (half-life): Not established in humans

Storage

Unreconstituted (powder) vials are usually kept refrigerated or frozen and away from light. Once mixed with bacteriostatic water, keep refrigerated and do not freeze; follow the supplier's stated beyond-use date.