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Peptide library › Cognitive & mood
Dihexa
Also known as PNB-0408
Experimental compound derived from angiotensin IV, studied in animals for memory.
What people use it for
- Memory and cognition (popular use)
- Alzheimer's disease (animal research)
What Dihexa does in the body
Strengthens signalling by hepatocyte growth factor (HGF) through its receptor, c-Met. In animal studies this encouraged new connections between neurons and improved performance in memory tasks.
Strength of evidence
Very weak: animal studies only; no published human trials.
Look up the evidence
- Reviews on PubMed: Summaries of the published research
- Clinical trials on PubMed: Published studies in people
- ClinicalTrials.gov: Registered trials, past and ongoing
Live searches of official databases. New to the terms? See the glossary.
Reported side effects & risks
- Unknown in humans
- Theoretical cancer concern, because the HGF/c-Met pathway can drive tumor growth
Who should avoid it or take extra care
- Pregnant or breastfeeding
- Under 18
- Current or past cancer (it may promote cell growth; theoretical)
Not a complete list. Check with a doctor or pharmacist about your own health and medicines.
Regulatory status
Not approved.
How it's taken
Route: By mouth, on the skin or injection (unofficial use)
How long it lasts (half-life): Not established in humans
Keep track of Dihexa privately
Fiala is a free app for logging doses, tracking vials and setting reminders. No account, and everything you log stays on your phone.
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