KPV

What people use it for

• Gut inflammation and colitis (animal research)
• Skin inflammation (research)

What KPV does in the body

The last three amino acids of alpha-melanocyte-stimulating hormone. It keeps alpha-MSH's anti-inflammatory activity, reducing NF-κB signalling inside cells, but does not cause tanning. In animal models it calmed inflammation in the bowel.

Strength of evidence

Weak: cell and animal studies; no meaningful human trials.

Look up the evidence

• Reviews on PubMed: Summaries of the published research
• Clinical trials on PubMed: Published studies in people
• ClinicalTrials.gov: Registered trials, past and ongoing

Live searches of official databases. New to the terms? See the glossary.

Reported side effects & risks

• Limited human safety data

Who should avoid it or take extra care

• Pregnant or breastfeeding
• Under 18

Not a complete list. Check with a doctor or pharmacist about your own health and medicines.

Regulatory status

Not approved.

How it's taken

Route: Capsules by mouth, creams, or injection (popular use)

How long it lasts (half-life): Short; not well established

Storage

Unreconstituted (powder) vials are usually kept refrigerated or frozen and away from light. Once mixed with bacteriostatic water, keep refrigerated and do not freeze; follow the supplier's stated beyond-use date.

Mixing guides

How much water to add and what each syringe mark holds, worked out for your own dose:

• 5 mg vial
• 10 mg vial

Found in these stacks

• KLOW: GLOW plus KPV: four peptides marketed for skin, recovery and inflammation.