Kisspeptin-10

What people use it for

• Fertility and IVF research
• Low testosterone and hypothalamic amenorrhea (research)
• Libido (research)

What Kisspeptin-10 does in the body

Kisspeptin activates GnRH neurons in the hypothalamus. These release GnRH, which tells the pituitary to release LH and FSH, the hormones that drive testosterone, estrogen and egg or sperm production.

Strength of evidence

Moderate in clinical research: human studies show reliable LH rises, and longer forms have been trialled to trigger egg maturation in IVF.

Look up the evidence

• Reviews on PubMed: Summaries of the published research
• Clinical trials on PubMed: Published studies in people
• ClinicalTrials.gov: Registered trials, past and ongoing

Live searches of official databases. New to the terms? See the glossary.

Reported side effects & risks

• Generally well tolerated in short studies
• Injection-site reactions
• Continuous exposure may blunt its effect

Who should avoid it or take extra care

• Pregnant or breastfeeding
• Hormone-sensitive cancers (such as breast or prostate)

Not a complete list. Check with a doctor or pharmacist about your own health and medicines.

Regulatory status

Not approved.

How it's taken

Route: Injection or drip in research settings

How long it lasts (half-life): Minutes

Storage

Unreconstituted (powder) vials are usually kept refrigerated or frozen and away from light. Once mixed with bacteriostatic water, keep refrigerated and do not freeze; follow the supplier's stated beyond-use date.

Mixing guides

How much water to add and what each syringe mark holds, worked out for your own dose:

• 5 mg vial
• 10 mg vial